abstract：:Type 1 diabetes (T1D) also known as juvenile diabetes is a chronic autoimmune disorder that precipitates in genetically susceptible individuals by environmental factors particularly during early age. Both genetic and epigenetic factors are implicated in the beta-cell development, proliferation, differentiation and fun...

journal_title：Chemico-biological interactions

authors： Khan S,Jena GB

更新日期：2014-04-25 00:00:00

abstract：:The monoterpene β-myrcene has been widely used in cosmetics, food and beverages, and it is normally found in essential oil from citrus fruit. The aim of this study was to investigate the anti-ulcer effects of β-myrcene on experimental models of ulcers that are induced by ethanol, NSAIDs (non-steroidal anti-inflammator...

journal_title：Chemico-biological interactions

authors： Bonamin F,Moraes TM,Dos Santos RC,Kushima H,Faria FM,Silva MA,Junior IV,Nogueira L,Bauab TM,Souza Brito AR,da Rocha LR,Hiruma-Lima CA

更新日期：2014-04-05 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BaP) are widely-distributed environmental contaminants known to exert toxic effects in various tissues, including placenta. PAHs have notably been shown to inhibit proliferation of trophoblastic cells. The present study was designed to determine whether P...

journal_title：Chemico-biological interactions

authors： Le Vee M,Kolasa E,Jouan E,Collet N,Fardel O

更新日期：2014-03-05 00:00:00

abstract：:Nuclear receptor activation in liver leads to coordinated alteration of the expression of multiple gene products with attendant phenotypic changes of hepatocytes. Peroxisome proliferators including endogenous fatty acids, environmental chemicals, and drugs induce a multi-enzyme metabolic response that affects lipid an...

journal_title：Chemico-biological interactions

authors： McMullen PD,Bhattacharya S,Woods CG,Sun B,Yarborough K,Ross SM,Miller ME,McBride MT,LeCluyse EL,Clewell RA,Andersen ME

更新日期：2014-02-25 00:00:00

abstract：:Dehydrogenase/reductase (SDR family) member 7 (DHRS7, retSDR4, SDR34C1) is a previously uncharacterized member of the short-chain dehydrogenase/reductase (SDR) superfamily. While human SDR members are known to play an important role in various (patho)biochemical pathways including intermediary metabolism and biotransf...

journal_title：Chemico-biological interactions

authors： Stambergova H,Skarydova L,Dunford JE,Wsol V

更新日期：2014-01-25 00:00:00

abstract：:Glucocorticoids therapy is strongly limited since extended glucocorticoids can cause serious side effects, including increased susceptibility to develop the bone disease osteoporosis. Despite its side effects recognized importance to clinicians, seldom is known about how glucocorticoids directly impact bone-forming os...

journal_title：Chemico-biological interactions

authors： Feng YL,Tang XL

更新日期：2014-01-25 00:00:00

abstract：:Organophosphourus compounds (OPC, including nerve agents and pesticides) exhibit acute toxicity by inhibition of acetylcholinesterase. Lung affections are frequent complications and a risk factor for death. In addition, epidemiological studies reported immunological alterations after OPC exposure. In our experiments w...

journal_title：Chemico-biological interactions

authors： Schäfer M,Koppe F,Stenger B,Brochhausen C,Schmidt A,Steinritz D,Thiermann H,Kirkpatrick CJ,Pohl C

更新日期：2013-12-05 00:00:00

abstract：:Organophosphate (OP) poisoning is still associated with high morbidity and mortality rates, both in resource-poor settings and in well-developed countries. Despite numerous publications dealing with this particular poison, detailed clinical data on more severe overdoses with these agents are relatively sparsely report...

journal_title：Chemico-biological interactions

authors： Hrabetz H,Thiermann H,Felgenhauer N,Zilker T,Haller B,Nährig J,Saugel B,Eyer F

更新日期：2013-12-05 00:00:00

abstract：:Punarnavine, a quinolizidine alkaloid isolated from Boerhaavia diffusa is known to possess analgesic, anti-inflammatory, hepato-protective, immunomodulatory and anti-proliferative properties. However, its roles in tumor angiogenesis and the involved molecular mechanism are still unknown. Therefore, we examined its ant...

journal_title：Chemico-biological interactions

authors： Saraswati S,Alhaider AA,Agrawal SS

更新日期：2013-11-25 00:00:00

abstract：:Due to increasing energy demand and limited fossil fuels, renewable energy sources have gained in importance. Particulate matter (PM) in general, but also PM from the combustion of wood is known to exert adverse health effects in human. These are often related to specific toxic compounds adsorbed to the PM surface, su...

journal_title：Chemico-biological interactions

authors： Gauggel-Lewandowski S,Heussner AH,Steinberg P,Pieterse B,van der Burg B,Dietrich DR

更新日期：2013-11-25 00:00:00

abstract：:The development of alcoholic liver diseases depends on the ability of hepatocyte to proliferate and differentiate in the case of alcohol-induced injury. Our previous work showed an inhibitory effect of alcohol on hepatocyte proliferation. However, the effect of alcohol on hepatocyte differentiation has not yet been pr...

journal_title：Chemico-biological interactions

authors： Do TH,Gaboriau F,Cannie I,Batusanski F,Ropert M,Moirand R,Brissot P,Loreal O,Lescoat G

更新日期：2013-11-25 00:00:00

abstract：:V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a member of CRK family and act as an adaptor protein participating in intra-cellular signal transduction. The role of CRKL in gastric cancer (GC) remains unclear. In this study, we show that CRKL was aberrantly highly expressed in both GC tumor specimens a...

journal_title：Chemico-biological interactions

authors： Wang J,Chen X,Li P,Su L,Yu B,Cai Q,Li J,Yu Y,Liu B,Zhu Z

更新日期：2013-11-25 00:00:00

abstract：:Interest in organoselenide chemistry and biochemistry has increased in the past three decades, mainly due to their chemical and biological activities. Here, we investigated the protective effect of the organic selenium compound diphenyl diselenide (PhSe)2 (5 μmol/kg), in a mouse model of methylmercury (MeHg)-induced b...

journal_title：Chemico-biological interactions

authors： Glaser V,Moritz B,Schmitz A,Dafré AL,Nazari EM,Rauh Müller YM,Feksa L,Straliottoa MR,de Bem AF,Farina M,da Rocha JB,Latini A

更新日期：2013-10-25 00:00:00

abstract：:The antioxidant mechanism of ebselen in rats brain is largely linked with its glutathione peroxidase (GPx) rather than its peroxiredoxin mimicry ability. However, the precise molecular dynamics between the GPx-mimicry of ebselen and thiol utilization is yet to be fully clarified and thus still open. Herein, we investi...

journal_title：Chemico-biological interactions

authors： Kade IJ,Balogun BD,Rocha JB

更新日期：2013-10-25 00:00:00

abstract：:Methylene diphenyl diisocyanate (MDI) is among the leading chemical causes of occupational asthma world-wide, however, the mechanisms of disease pathogenesis remain unclear. This study tests the hypothesis that glutathione (GSH) reacts with MDI to form quasi-stable conjugates, capable of mediating the formation of MDI...

journal_title：Chemico-biological interactions

authors： Wisnewski AV,Liu J,Redlich CA

更新日期：2013-09-05 00:00:00

abstract：:Inflammation and oxidative stress exert important roles in intestinal ischemia-reperfusion injury (IRI). Lycium barbarum polysaccharides (LBPs) have shown effective antioxidative and immunomodulatory functions in different models. The purpose of the present study was to assess the effects and potential mechanisms of L...

journal_title：Chemico-biological interactions

authors： Yang X,Bai H,Cai W,Li J,Zhou Q,Wang Y,Han J,Zhu X,Dong M,Hu D

更新日期：2013-08-25 00:00:00

abstract：:Baicalin has been shown to possess many pharmacological effects, including antiviral, antioxidant, anti-cancer and anti-inflammatory properties. In the current study, we reveal the inhibitory effects of baicalin on the metabolism of dextromethorphan (DXM), a dual probe substrate of CYP2D and CYP3A, in rats. Lineweaver...

journal_title：Chemico-biological interactions

authors： Tian X,Cheng ZY,He J,Jia LJ,Qiao HL

更新日期：2013-04-25 00:00:00

abstract：:Avermectin (AVM) is a macrocyclic lactone agent widely used as a nematicide, acaricide and insecticide in veterinary medicine and plant protection. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump for xenobiotic compounds, and is involved in multidrug resistance. To understand the development of AVM resistan...

journal_title：Chemico-biological interactions

authors： Luo L,Sun YJ,Yang L,Huang S,Wu YJ

更新日期：2013-04-25 00:00:00

abstract：:Butyrylcholinesterase (BChE) has been associated to body mass index (BMI), weight, cholesterol and triglyceride levels. -116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been associated to BChE activity, weight and BMI variance in adults. The present study examined -116A and K variant...

journal_title：Chemico-biological interactions

authors： Chaves TJ,Leite N,Milano GE,Milano GE,Souza RL,Chautard-Freire-Maia EA,Furtado-Alle L

更新日期：2013-03-25 00:00:00

abstract：:The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflamma...

journal_title：Chemico-biological interactions

authors： Wang Y,Wei Y,Oguntayo S,Doctor BP,Nambiar MP

更新日期：2013-03-25 00:00:00

abstract：:In Alzheimer's disease (AD) a reduction in acetylcholinesterase (AChE) and an increase in butyrylcholinesterase (BChE) activity are observed. K variant (539T) is the most common variant of the BCHE gene and, although controversial, several studies reported association between K variant and AD. Previous results showed ...

journal_title：Chemico-biological interactions

authors： Simão-Silva DP,Bertolucci PH,de Labio RW,Payão SL,Furtado-Alle L,Souza RL

更新日期：2013-03-25 00:00:00

abstract：:Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. In this paper, we report that B12H (24-h pretreatment) effectively blocked glutamate-induced neuronal excitotoxicity in cerebellar granule neurons (CGNs). Howev...

journal_title：Chemico-biological interactions

authors： Cui W,Hu S,Chan HH,Luo J,Li W,Mak S,Choi TC,Rong J,Carlier PR,Han Y

更新日期：2013-03-25 00:00:00

abstract：:Butyrylcholinesterase (BuChE) is found to have a brain distribution pattern that is distinct from that of acetylcholinesterase (AChE). Neurons containing BuChE are particularly located in the amygdala, hippocampal formation and the thalamus, structures involved in the normal functions of cognition and behavior that ty...

journal_title：Chemico-biological interactions

authors： Darvesh S

更新日期：2013-03-25 00:00:00

abstract：:We are investigating treatments for cocaine abuse based on viral gene transfer of a cocaine hydrolase (CocH) derived from human butyrylcholinesterase, which can reduce cocaine-stimulated locomotion and cocaine-primed reinstatement of drug-seeking behavior in rats for many months. Here, in mice, we explored the possibi...

journal_title：Chemico-biological interactions

authors： Brimijoin S,Orson F,Kosten TR,Kinsey B,Shen XY,White SJ,Gao Y

更新日期：2013-03-25 00:00:00

abstract：:Butyrylcholinesterase (BChE) is the leading pretreatment candidate against exposure to organophosphates (OPs), which pose an ever increasing public and military health. Since respiratory failure is the primary cause of death following acute OP poisoning, an inhaled BChE therapeutic could prove highly efficacious in pr...

journal_title：Chemico-biological interactions

authors： Rosenberg YJ,Laube B,Mao L,Jiang X,Hernandez-Abanto S,Lee KD,Adams R

更新日期：2013-03-25 00:00:00

abstract：:Since Duchenne muscular dystrophy was attributed to mutations in the dystrophin gene, more than 30 genes have been found to be causally related with muscular dystrophies, about half of them encoding proteins of the dystrophin-glycoprotein complex (DGC). Through laminin-2, the DGC bridges the muscle cytoskeleton and th...

journal_title：Chemico-biological interactions

authors： Vidal CJ,Montenegro MF,Muñoz-Delgado E,Campoy FJ,Cabezas-Herrera J,Moral-Naranjo MT

更新日期：2013-03-25 00:00:00

abstract：:The genome of Escherichia coli K12 contains 9 open reading frames encoding aldo/keto reductases (AKRs) that are differentially regulated and sequence diverse. A significant amount of data is available for the E. coli AKRs through the availability of gene knockouts and gene expression studies, which adds to the biochem...

journal_title：Chemico-biological interactions

authors： Lapthorn AJ,Zhu X,Ellis EM

更新日期：2013-02-25 00:00:00

abstract：:Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Additionally, cancer progression may be partly regu...

journal_title：Chemico-biological interactions

authors： Miura T,Taketomi A,Nishinaka T,Terada T

更新日期：2013-02-25 00:00:00

abstract：:Buttiauxella strain S19-1 is a new marine bacterium, isolated from the Baltic Sea, which can degrade steroids. In this report, a meta-genomic approach was used to isolate estradiol inducible genes from S19-1. SalI-fragments from the chromosomal DNA of S19-1 were ligated into plasmid pKEGFP2 bearing an EGFP gene as the...

journal_title：Chemico-biological interactions

authors： Zhang T,Xiong G,Maser E

更新日期：2013-02-25 00:00:00

abstract：:Until the last decade, two unrelated aldehyde dehydrogenase (ALDH) superfamilies, i.e. the phosphorylating and non-phosphorylating superfamilies, were known to catalyze the oxidation of aldehydes to activated or non-activated acids. However, a third one was discovered by the crystal structure of a bifunctional enzyme ...

journal_title：Chemico-biological interactions

authors： Fischer B,Boutserin S,Mazon H,Collin S,Branlant G,Gruez A,Talfournier F

更新日期：2013-02-25 00:00:00

abstract：:Previous studies have reported that cimetidine, an H2-receptor antagonist used to treat gastric and duodenal ulcers, can inhibit alcohol dehydrogenases (ADHs) and ethanol metabolism. Human alcohol dehydrogenases and aldehyde dehydrogenases (ALDHs), the principal enzymes responsible for metabolism of ethanol, are compl...

journal_title：Chemico-biological interactions

authors： Lai CL,Li YP,Liu CM,Hsieh HS,Yin SJ

更新日期：2013-02-25 00:00:00

abstract：:Functional activity of neurotransmitter receptor and their sensitivity to regulation are altered in DM. We evaluated the neuroprotective effect of curcumin in glutamate mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rats. Gene expression studies in diabetic rats showed a down regulation ...

journal_title：Chemico-biological interactions

authors： Jayanarayanan S,Smijin S,Peeyush KT,Anju TR,Paulose CS

更新日期：2013-01-25 00:00:00

abstract：:Phagocytic cells, especially neutrophils (PMNs) are specialized in the production of reactive oxygen species (ROS) to kill pathogenic agents, but an excessive ROS production is associated with tissue damages and inflammatory diseases. Phagocytes are thus prime therapeutic targets to control inflammatory events associa...

journal_title：Chemico-biological interactions

authors： Derochette S,Franck T,Mouithys-Mickalad A,Deby-Dupont G,Neven P,Serteyn D

更新日期：2013-01-25 00:00:00

abstract：:A few organophosphorus compounds (OPs) can cause toxic neuropathy known as organophosphorus ester-induced delayed neuropathy (OPIDN). Although the incidents of OPIDN have been documented for over a century, its molecular mechanisms underlying the axonopathy are still unclear. Recently, increasing evidences suggest tha...

journal_title：Chemico-biological interactions

authors： Song F,Xie K

更新日期：2012-12-05 00:00:00

abstract：:A multi-compartment physiologically based pharmacokinetic (PBPK) model was developed to describe the behavior of Cr(III) and Cr(VI) in rats and mice following long-term oral exposure. Model compartments were included for GI lumen, oral mucosa, forestomach/stomach, small intestinal mucosa (duodenum, jejunum, ileum), bl...

journal_title：Chemico-biological interactions

authors： Kirman CR,Hays SM,Aylward LL,Suh M,Harris MA,Thompson CM,Haws LC,Proctor DM

更新日期：2012-10-25 00:00:00

abstract：:The electrophilic metabolites of the polyaromatic hydrocarbon naphthalene have been shown to bind covalently to proteins and covalent adduct formation correlates with the cytotoxic effects of the chemical in the respiratory system. Although 1,2-naphthalene epoxide, naphthalene diol epoxide, 1,2-naphthoquinone, and 1,4...

journal_title：Chemico-biological interactions

authors： Pham NT,Jewell WT,Morin D,Buckpitt AR

更新日期：2012-08-30 00:00:00

abstract：:Zinc oxide (ZnO) nanoparticles are one of the important industrial nanoparticles. The production of ZnO nanoparticles is increasing every year. On the other hand, it is known that ZnO nanoparticles have strong cytotoxicity. In vitro studies using culture cells revealed that ZnO nanoparticles induce severe oxidative st...

journal_title：Chemico-biological interactions

authors： Fukui H,Horie M,Endoh S,Kato H,Fujita K,Nishio K,Komaba LK,Maru J,Miyauhi A,Nakamura A,Kinugasa S,Yoshida Y,Hagihara Y,Iwahashi H

更新日期：2012-06-25 00:00:00

abstract：:Except for their extra- and intra-cellular interfaces, cell membranes are hydrophobic and inhibit the transport of hydrophilic molecules. Metalloids in aqueous solutions form chemical species with oxygen and hydroxyl groups and, therefore, exist as hydrophilic neutral polar solutes or as hydrophilic anions. This chara...

journal_title：Chemico-biological interactions

authors： Zangi R,Filella M

更新日期：2012-04-15 00:00:00

abstract：:We investigated the chemopreventive effect of p-methoxycinnamic acid (p-MCA), an active phenolic acid of rice bran, turmeric, and Kaemperfia galanga against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Male albino Wistar rats were randomly divided into six groups. Group 1 consisted of control rats that rece...

journal_title：Chemico-biological interactions

authors： Sivagami G,Karthikkumar V,Balasubramanian T,Nalini N

更新日期：2012-03-05 00:00:00

abstract：:Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidan...

journal_title：Chemico-biological interactions

authors： Granado-Serrano AB,Martín MA,Bravo L,Goya L,Ramos S

更新日期：2012-01-25 00:00:00